Outside of the endocrine system, there is an oncocytic variant of renal cell carcinoma, and salivary glands, particularly the parotid, develop oncocytic nodules and tumours. Melanotic variant of oncocytic metaplasia of the nasopharynx is an extremely rare condition. They may be indications of other medical conditions such as inflammation of the thyroid gland or a noncancerous enlargement of the thyroid goiter. This authoritative, concise reference book provides an international standard for oncologists and pathologists and will serve as an indispensable guide for use in the design of studies. Oxyphilic oncocytichurthle cell variant of ptc solid variant of ptc tall cell variant of ptc columnar variant of ptc hobnail variant of ptc references. Oncocytic oxyphilic, hurthle cell like cytoplasm but nuclear features of papillary carcinoma. Pituitary metastases from the oncocytic variant of follicular. Disease bioinformatics research of oncocytic metaplasia has been linked to metaplasia, neoplasms, oncocytic neoplasm, carcinoma, hyperplasia. Oxyphilic oncocytic change may occur as a focal finding in conventional ptc or may be more widespread in 3 uncommonrare variants. Jan 16, 2014 by light microscopy, hurthle cells refer to modified follicular cells exhibiting abundant finely granular cytoplasm, a round nucleus, and a variably conspicuous nucleolus. Carcinoma, follicular oncocyticoxyphilic cell variant 99fp carcinoma, follicular poorly differentiated carcinoma, follicular trabecular type 99fw carcinoma, follicular well differentiated 99fc carcinoma, follicular, microinvasive 96gi carcinoma, giant cell 96gc carcinoma, glassy cell 93gl carcinoma, glycogenrich carcinoma, glycogen. Oncocytictype intraductal papillary mucinous neoplasm. Oncocytictype intraductal papillary mucinous neoplasm ipmn, first identified by ohhashi et al. Oncocytic metaplasia in inflammatory fibrous hyperplasia oncocytic metaplasia in inflammatory fibrous hyperplasia.
Make an appointment with your doctor if you have any signs or symptoms that worry you. Hurthle cell thyroid gland only oxyphilic cell, apocrine metaplasia breast gland only. Oncocytes are large cells with abundant eosinophilic granular cytoplasm. Cribriformmorular variant of ptc warthinlike variant of ptc diffuse sclerosing variant of ptc oxyphilic oncocytic hurthle cell variant of ptc solid variant of ptc tall cell variant of ptc columnar variant of ptc hobnail variant of ptc references. Thyroid oncocytic tumors represent approximately 510% of thyroid neoplasms. Seroustype acini of a parotid gland with dense secretory granules histologic section of a submaxillary gland. Absence of the braf and the grim19 mutations in oncocytic. Oxyphilic and nonoxyphilic thyroid carcinoma cell lines. The international classification of diseases for oncology icdo is a domainspecific extension of the international statistical classification of diseases and related health problems for tumor diseases. Oncocytic variant of medullary thyroid carcinoma a case. Oncocytic variant of medullary thyroid carcinoma is an extremely rare entity and only 17 cases have been reported in the literature until 8 1 f 54 single lesion nd dominguez malagon et al. Oncocytictype intraductal papillary mucinous neoplasm ipmn. Department of pathology and laboratory medicine, university of vermont fletcher. Because of this focality, these tumors are rarely confused as oncocytic by fna cytology.
The oncocytic variant of papillary thyroid carcinoma. The oxyphilic hurthle cell type may be more aggressive than usual ptc. The nodules were biopsied to determine the histology. Minimally invasive follicular thyroid carcinoma can be diagnosed when there is up to full capsular invasion, small. A clinicopathologic study of minimally invasive follicular. Clear cell variant of fibrolamellar carcinoma of the liver. It is usually advanced that the absence of an oncocytic hurthle cell variant of undifferentiated carcinoma utc. Many investigators have suggested that these tumors originate from intercalated cells of the collecting system.
Oncocytic type intraductal papillary mucinous neoplasm ipmn, first identified by ohhashi et al. Hurthle cell cancer symptoms and causes mayo clinic. Information and translations of oncocytic in the most comprehensive dictionary definitions resource on the web. The mean age at diagnosis was 43 years for adenomas and 52 for oncocytic carcinomas in a recent series. Random cytochromecoxidase deficiency of oxyphil cell nodules in the.
Atlas of endocrine pathology pdf download direct link. International classification of diseases for oncology. This is a recent advances in histopathology presentation on metaplastic changes and abnormal behaviour of glands. The follicular variant is less favorable than typical ptc. This website is intended for pathologists and laboratory personnel, who understand that medical information is imperfect and must be interpreted using reasonable medical judgment. Braf v600e mutation can be found in oncocytic papillary thyroid carcinoma but is much more prevalent in tall cell variant of papillary thyroid carcinoma. We studied 15 cases of thyroid tumors predominantly composed of oncocytic oxyphilic cells that were characterized by showing.
Pituitary metastases from the oncocytic variant of. We studied 15 cases of thyroid tumors predominantly composed of oncocytic oxyphilic cells that were characterized by showing the classical nuclear features of papillary carcinoma of the thyroid. Predictive value of the fineneedle aspiration diagnosis. Mediakit reprints and eprints sponsored supplements branded books. An oncocyte is an epithelial cell characterized by an excessive number of mitochondria, resulting in an abundant acidophilic, granular cytoplasm. Oncocytic changes are seen in other thyroid cancer hurthle cell carcinoma, medullary carcinoma and in other variants of papillary carcinoma tall cell variant, warthinlike variant ptc variants with oncocytic changes may have overlapping morphology and patterns. Who classification of tumours of the urinary system and. Besides these defined neoplasms, there are other entities that are not well identified oncocytic changes of the parotid gland, such as oncocytic metaplasia, diffuse oncocytosis. Squamous and oncocytic metaplasia in salivary gland tumors j. Accumulation of p27kip1 is associated with cyclin d3 overexpression in the oxyphilic hurthle cell variant. The clinical differential diagnosis was malignant melanoma or hemangioma.
The study of oncocytic metaplasia has been mentioned in research publications which can be found using our bioinformatics tool below. Oxyphilic tumors of the thyroid are characterized by mitochondrionrich cells and extensive dna fragmentation. Oxyphilic definition of oxyphilic by medical dictionary. The oncocytic variant of papillary carcinoma of the thyroid. Oncocytic carcinoma oncocytic carcinoma is a rare tumor, found mainly in the parotid gland. Intraductal oncocytic papillary neoplasm of the pancreas. The oncocytic variant of medullary thyroid carcinoma is rare. On fine needle aspiration cytology fnac, a hurthle cell neoplasm was suggested. The study of oxyphilic adenocarcinoma has been mentioned in research publications which can be found using our bioinformatics tool below.
Primary oncocytic adenocarcinomas of the lung american journal. According to the most recent world health organization who classification, the current correct term for hcc is actually oncocytic carcinoma. In the thyroid gland, the oncocytic cell is considered to be a synonym for hurthle, oxyphilic, eosinophilic, or askanazy cell. Portion of a parotid gland demonstrating multiple foci of sebaceous differentiation. Pdf my approach to oncocytic tumors of the thyroid researchgate. Hccs with strongly eosinophilic and granular cells form the oxyphilic and oncocytic variants of hcc, the latter having increased number of. Melanotic oncocytic metaplasia of the nasopharynx as a. The oncocytic variant of papillary carcinoma of the. The true oncocytic cells are derived from follicular cells, whereas hurthle described parafollicular calcitoninproducing cells.
In order to clarify if a different expression of apoptosisrelated genes could be responsible for dna fragmentation in oxyphilic cell tumors, two thyroid follicular carcinomaderived cell lines, having oxyphilic xtc. Oncocytic cells of the thyroid was first described by askanazy but are also known as hurthle or oxyphilic cells 30. The oncocytic variant of mtc is an extremely rare diagnosis, with less than 20 cases reported. Whether youve loved the book or not, if you give your honest and detailed thoughts then people will find new books that are right for them. Oncocytic tumours composed predominantly or exclusively of oncocytic cells are rare. Who classification of tumours of the urinary system and male genital organs is the eighth volume in the 4th edition of the who series on histological and genetic typing of human tumours. The oncocytic variant of papillary carcinoma of the thyroid represents an unusual neoplasm whose clinicopathological features and biological behavior have not been thoroughly characterized. The first case of renal oncocytoma was reported by zippel in 1942.
Oncocytic papillary thyroid carcinomas show accumulation of mitochondrial dna mutations. We studied 15 cases of thyroid tumors predominantly composed of oncocytic oxyphilic cells that were characterized by showing the classical nuclear features. Several variants of papillary carcinoma have been described considering. Poorly differentiated and undifferentiated thyroid carcinomas. We studied 15 cases of thyroid tumors predominantly composed of oncocytic oxyphilic cells that were characterized by showing the classical nuclear. Reliable information about the coronavirus covid19 is available from the world health organization current situation, international travel. Pdf oncocytic variant of medullary thyroid carcinoma. Oncocytic metaplasia in inflammatory fibrous hyperplasia med oral patol oral cir bucal. Oncocytic metaplasia is a common but focal phenomenon in several other salivary gland neoplasms including acc, pleomorphic adenoma, mucoepidermoid carcinoma, and myoepithelioma, plasmacytoid type. The histopathology is marked by sheets of large swollen polyhedral epithelial oncocytes, which are granular acidophilic parotid cells with centrally located nuclei.
All books videos on the med syndicate are free and. Fibrolamellar carcinoma of the liver is an uncommon but distinctive type of hepatocellular carcinoma hcc first described by edmondson in 1956 and later popularized in the 1980s by berman et al1 and craig et al. There is a female preponderance in both subgroups, with a femaletomale ratio of 8. Asa suggests that is no logical basis to separate oncocytic lesions from other classifications of thyroid pathology j clin pathol 2004. The concept of classifying oncocytic lesions, including follicular variant papillary carcinomas, based on. Since then this tumor have been described as proximal tubular adenoma with oncocytic features and later oncocytoma became the generally accepted term. Oncocytic metaplasia in inflammatory fibrous hyperplasia. Plasma cells or lymphohistiocytic aggregates were not seen in this aspirate. However, formatting rules can vary widely between applications and fields of interest or study. Intraductal oncocytic papillary neoplasm iopn is a rare subset of intraductal. It comprises about 1% of all salivary gland tumors.
A 73yearold japanese man presented with nasal congestion and chill. Other readers will always be interested in your opinion of the books youve read. Oncocytic and oncocytelike lesions of the head and neck. Oncocytic change, either focal or diffuse, is a rare feature of mucoepidermoid carcinoma. A normal human thyroid gland contains 20 to 30 million spherical follicles lined with follicular epithelial cells filled with colloid and stores a 3 months supply of thyroid hormone. Tallcell carcinoma is a more aggressive form of thyroid carcinoma that differs from the usual form by showing tall columnar cells. Numerous and frequentlyupdated resource results are available from this search. In addition, other tumors or subtypes of tumors with oncocytic features include warthin tumor, the oncocytic variant of mucoepidermoid carcinoma, pleomorphic adenoma with oncocytic features, oncocytic carcinoma, and metastatic tumors, especially renal cell carcinoma. Variants of papillary thyroid carcinoma turkish journal of pathology.
The salivary gland oncocytoma is a wellcircumscribed, benign neoplastic growth also called an oxyphilic adenoma. Here we present the case of a 36yearold male patient with complaints of neck swelling and dysphagia. Earlier it was thought that hccs behave more aggressively than follicular carcinomas but later no statistically significant difference in the rate of local recurrence, metastasis, or patient survival was found. Hurthle cell carcinoma, a variant of follicular thyroid carcinoma. The new 4th edition world health organization classification for. Ebscohost serves thousands of libraries with premium essays, articles and other content including the oncocytic variant of papillary thyroid carcinoma. Jan 30, 2020 these signs and symptoms dont necessarily mean you have hurthle cell cancer. Jun 30, 2012 oncocytic variant of prostatic adenocarcinoma is a very rare variant and to date very few cases have been reported4,5.
Oncocytic tumours are found in the thyroid and other endocrine tissues, including the parathyroid, pituitary, adrenal cortex, pancreas, gut, and lung. No prognostic significance has been associated with it because there are not enough cases to be followed up. Lateral neck dissection was performed in 5 24% oncocytic variant and classical ptc patients, with metastatic lymphadenopathy found in four a median of four malignant lymph nodes. Histopathological and immunohistochemical analysis. Nasoscopic examination revealed multiple black nodules around the bilateral torus tubarius. This classification is widely used by cancer registries it is currently in its third revision icdo3. Oncocytic adenoma definition of oncocytic adenoma by. Sep 01, 2001 fibrolamellar carcinoma of the liver is an uncommon but distinctive type of hepatocellular carcinoma hcc first described by edmondson in 1956 and later popularized in the 1980s by berman et al1 and craig et al. Disease bioinformatics research of oxyphilic adenocarcinoma has been linked to carcinoma, neoplasms, thyroid neoplasm, oncocytic neoplasm, malignant neoplasms. Sixteen cases of primary oncocytic adenocarcinomas of the lung are reported. Melanotic oncocytic metaplasia of the nasopharynx as a benign. The oncocytic variant shows a papillary growth pattern with nuclear features of ptc combined with cytoplasm that is. Oclcs webjunction has pulled together information and resources to assist library staff as they consider how to handle.
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